Foxk 1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo 4 and Mef 2 factors
نویسندگان
چکیده
Lillehei Heart Institute, University of Minnesota-Twin Cities, Minneapolis, MN 55455 Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061 Belfer Institute for Applied Cancer Science, Departments of Medical Oncology, Medicine and Genetics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115
منابع مشابه
Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2.
In response to severe injury, adult skeletal muscle exhibits a remarkable regenerative capacity due to a resident muscle stem/progenitor cell population. While a number of factors are expressed in the muscle progenitor cell (MPC) population, the molecular networks that govern this cell population remain an area of active investigation. In this study, utilizing knockdown techniques and overexpre...
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Insulin-like growth factors (IGFs) stimulate myoblast proliferation and differentiation. It remains elusive how these mutually exclusive cellular responses are elicited by the same growth factor. Here we report that whereas IGF promotes myoblast differentiation under normoxia, it stimulates proliferation under hypoxia. Hypoxia activates the HIF-1 transcriptional program and knockdown of HIF-1al...
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تاریخ انتشار 2012